Drug Category: Selective serotonin reuptake inhibitors
Their action is linked to reducing uptake of serotonin in the central nervous system. SSRIs have weak effects on norepinephrine and dopamine neuronal reuptake. They do not antagonize adrenergic, cholinergic, GABA, dopaminergic, histaminergic, serotonergic, or benzodiazepine receptors; this means they have fewer adverse anticholinergic effects than the family of tricyclic antidepressants.
SSRIs cause sexual side effects, including delay in sexual orgasm for both men and women; while delayed in reaching orgasm caused by an SSRI is an adverse effect in women, the same may not be true in men. Indeed, it can help to overcome too-rapid orgasm. Sertraline (Zoloft), paroxetine (Paxil), and fluoxetine (Prozac) are helpful SSRIs for treating premature ejaculation.
The optimal treatment for premature ejaculation is unknown, but single dosing before sex works for some men, while daily use of the medication may be necessary for others. The daily dose may be increased gradually until a therapeutic effect is achieved. If one SSRI doesn’t help, using a second alternative is reasonable. After 6 weeks at maximal dose with no improvement, no further treatment is recommended